Updated April 29, 2026
Agno (formerly Phidata) is an open-source Python framework for building production-grade AI agents and multi-agent systems. 39K+ GitHub stars, 23+ LLM providers supported, 100+ pre-built tool integrations, MCP-compatible. Includes AgentOS — a stateless FastAPI runtime — and a control plane UI for monitoring.
Dify is an open-source platform for building LLM applications with both visual and code-based interfaces. It provides a workflow orchestration engine, RAG pipeline builder, agent framework, and model management—all accessible through a web UI. Dify supports 50+ LLM providers, offers enterprise features like SSO and access control, and can be self-hosted or used as a cloud service.
Core capabilities each platform advertises.
What each tool does well, and the limitations to keep in mind.
Pros
Cons
Pros
Cons
Agno has emerged as one of the fastest-growing AI agent frameworks in 2026 — 39,100+ stars and a 424-contributor community.
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Respan lets you trace LLM and agent calls across any model or framework, A/B test prompts on production traffic, and route requests across 500+ models through one gateway.