Updated April 29, 2026
AutoGen is Microsoft's open-source framework for building multi-agent AI systems. It enables the creation of conversational agents that can work together, use tools, and interact with humans to solve complex tasks. AutoGen supports customizable agent behaviors, flexible conversation patterns, and integrations with various LLMs. The framework is popular for building research assistants, coding agents, and automated analysis pipelines.
Hermes Agent is Nous Research's open-source autonomous AI agent with persistent memory across sessions. Released February 2026; hit 95.6K GitHub stars in seven weeks. Memory persists in ~/.hermes/memories/ plus 8 external provider plugins (Mem0, Honcho, OpenViking, etc.). Self-creates skills that compound over months of use.
Core capabilities each platform advertises.
What each tool does well, and the limitations to keep in mind.
Pros
Cons
Pros
Cons
Released February 2026; seven weeks later it hit 95,600 GitHub stars — the fastest-growing agent framework of 2026.
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Respan lets you trace LLM and agent calls across any model or framework, A/B test prompts on production traffic, and route requests across 500+ models through one gateway.