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Introducing Respan Router

Mastra vs Semantic Kernel (2026)

Updated March 10, 2026

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Overview

Rating
10.0 / 10
Rating
10.0 / 10
Best For
TypeScript developers who want a modern framework for building production AI agents
Best For
Enterprise .NET developers building AI applications on Microsoft infrastructure
Product Summary

Mastra is a TypeScript-first agent framework for building production AI applications. It provides primitives for agents, workflows, RAG, integrations, and memory with a focus on developer experience and type safety. Mastra is designed for full-stack TypeScript developers who want to build AI features without leaving their existing tech stack.

Product Summary

Semantic Kernel is Microsoft's enterprise SDK for integrating AI into applications. It provides planners for multi-step task execution, plugin architectures for tool use, memory systems, and connectors for all major LLM providers. Available in C#, Python, and Java, Semantic Kernel is designed for enterprise .NET shops building AI-powered features into existing applications.

Starting Price
$0Per month
Starting Price
$0Per month
Free Trial
Yes
Free Trial
Yes
Free Version
Yes
Free Version
Yes
Website

Key features

Core capabilities each platform advertises.

MastraMastra
  • TypeScript agent framework
  • Built-in tool calling and workflows
  • Sync engine for agent state
  • Integration marketplace
  • Production-ready agent primitives
Semantic KernelSemantic Kernel
  • Enterprise AI orchestration by Microsoft
  • C# and Python SDKs
  • Plugin architecture for tools
  • Memory and planning capabilities
  • Azure and Microsoft 365 integration

Strengths and tradeoffs

What each tool does well, and the limitations to keep in mind.

MastraMastra

Pros

  • Production-ready platform
  • Good performance
  • Active development
  • Strong features

Cons

  • Enterprise pricing varies
  • Setup complexity
  • Learning curve required
Semantic KernelSemantic Kernel

Pros

  • Free open-source
  • Microsoft-backed
  • Multi-language

Cons

  • Learning curve
  • Microsoft focus

Mastra or Semantic Kernel — which should you choose?

Choose Mastra if you want

  • TypeScript-native agent development
  • Building AI workflows with tool use
  • Agent state management
  • Production agent deployment
  • Multi-step task automation

Choose Semantic Kernel if you want

  • Enterprise AI on Microsoft stack
  • Copilot-style applications
  • Integrating AI into .NET applications
  • Microsoft 365 automation
  • Enterprise workflow orchestration

Compare Mastra and Semantic Kernel on your own traffic

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1,000+Models
5 minSetup

Respan lets you trace LLM and agent calls across any model or framework, A/B test prompts on production traffic, and route requests across 1,000+ models through one gateway.

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Frequently Asked Questions

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