What is CalypsoAI?
CalypsoAI is a pioneering AI security company founded in 2018 that provides the only full-lifecycle platform to secure AI agents and applications at the inference layer. Headquartered in Dublin, Ireland with operations in New York, CalypsoAI has established itself as a leader in enterprise AI security through its innovative 'Agentic Warfare' approach to protecting organizations from evolving AI threats. The company's technology deploys a comprehensive 'test–defend–observe' stack that protects applications, APIs, models, and agents throughout the AI lifecycle.
CalypsoAI has earned significant industry recognition, including being a Top-Two Finalist in the 2025 RSAC Innovation Sandbox contest and one of Fast Company's Most Innovative Companies in AI for 2025. The company secured over USD 40 million in venture funding from prominent investors including Paladin Capital Group, Lockheed Martin Ventures, and Hakluyt Capital, demonstrating strong confidence in its security-first approach to AI.
In September 2025, F5 Networks acquired CalypsoAI for USD 180 million, positioning F5 as the first major vendor to embed comprehensive AI-native security directly into application delivery infrastructure. CalypsoAI's technology is trusted by global enterprises including Palantir and SGK, and the acquisition enables F5 to integrate CalypsoAI's enterprise-ready security capabilities into the F5 Application Delivery and Security Platform, providing enhanced protection for AI-powered applications at scale.
Pros & Cons
Pros
- +Only full-lifecycle platform for AI security at inference layer
- +Strong industry recognition including RSAC Innovation Sandbox finalist
- +Trusted by major enterprises like Palantir and SGK
- +USD 180M F5 acquisition validates technology and market position
Cons
- -Enterprise-only pricing may be prohibitive for smaller organizations
- -Complex security features require expertise to implement
- -Now owned by F5, which may change product direction
CalypsoAI Pricing
- ✓Full-lifecycle AI security
- ✓Inference layer protection
- ✓Test-defend-observe stack
- ✓Application and API security
- ✓Model and agent protection
- ✓Dedicated support
- ✓SLA guarantees
Using CalypsoAI with Respan
Integrate CalypsoAI's enterprise AI security platform with Respan to add comprehensive protection to your AI workflows. Secure your AI agents and applications at the inference layer with CalypsoAI's test-defend-observe approach. Through Respan's platform, you can ensure that all AI interactions are protected against evolving threats while maintaining performance and reliability.
- ✓Protect AI applications with full-lifecycle security
- ✓Secure inference layer against adversarial attacks
- ✓Monitor and defend AI agents with real-time threat detection
- ✓Maintain compliance with enterprise security standards
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Last verified: March 10, 2026