Updated March 10, 2026
AutoGen is Microsoft's open-source framework for building multi-agent AI systems. It enables the creation of conversational agents that can work together, use tools, and interact with humans to solve complex tasks. AutoGen supports customizable agent behaviors, flexible conversation patterns, and integrations with various LLMs. The framework is popular for building research assistants, coding agents, and automated analysis pipelines.
CrewAI is a framework for orchestrating multi-agent AI systems where specialized agents collaborate to complete complex tasks. It provides abstractions for defining agent roles, goals, tools, and workflows, enabling teams of AI agents to work together like a human crew. CrewAI supports sequential, parallel, and hierarchical task execution patterns and integrates with all major LLM providers.
Core capabilities each platform advertises.
What each tool does well, and the limitations to keep in mind.
Pros
Cons
Pros
Cons
Choose AutoGen if you wantChoose if you want
Choose CrewAI if you wantChoose if you want
Respan lets you trace LLM and agent calls across any model or framework, A/B test prompts on production traffic, and route requests across 500+ models through one gateway.